Description
5-Methyltetrahydrofolate (5-MTHF) is the bioactive form of vitamin B9 (folate), naturally present in certain foods and readily utilized by the body. It plays a role in DNA synthesis, cellular repair, and methylation, supporting metabolic function. This compound is essential during pregnancy for fetal development and neural tube formation. 5-MTHF also contributes to red blood cell production and homocysteine metabolism. For individuals with MTHFR mutations, adequate dietary folate intake plays a key role in supporting metabolic balance and overall health.
Functions in the Body
Category
Deficiency Symptoms
Members unlock a concise, item-specific overview of what low levels (or low functional availability) may be associated with, written in neutral, non-diagnostic terms and limited to commonly referenced deficiency-pattern symptoms where applicable
Synergists & Antagonists
Members unlock practical pairing and separation notes that cover both supportive combinations and common blockers (supplements, fibers, binders, and absorption modifiers), plus clear “avoid/space” guidance where interactions are plausible
5-Methyltetrahydrofolate
Warnings
A number of medications, including high doses of NSAIDs (e.g., Ibuprofen, Aspirin), anticonvulsants, cholesterol-lowering agents, methotrexate, trimethoprim, oral contraceptives, and blood pressure medications can interfere with folate metabolism. Consult your healthcare provider if you're on any of these medications.
Food Sources
5-MTHF is supported by foods high in folate, including turkey, chicken, pumpkin seeds, spinach, milk, bananas, broccoli, legumes, and asparagus.
Time Frame
Members unlock simple timing guidance (with meals vs empty stomach, morning vs evening where it matters), keeping it consistent and practical without over-prescribing exact schedules
Disclaimer
Information on this page is for general educational purposes and is not medical advice. Nutrients and bioactive compounds can interact with medications and may cause adverse effects; consult a qualified clinician before use if on medication, pregnant/breastfeeding, under 18, or managing a medical condition. Stop use and seek medical advice if concerning symptoms occur.